Livedoid vasculitis - Livedoid Αγγειίτιδα
Η Livedoid Αγγειίτιδα (Livedoid vasculitis) είναι μια χρόνια δερματική νόσος που εμφανίζεται κυρίως σε νεαρές έως μέσης ηλικίας γυναίκες. Ένα αρκτικόλεξο που χρησιμοποιείται για να περιγράψει τα χαρακτηριστικά του είναι «Επώδυνα πορφυρικά έλκη με δικτυωτό σχέδιο των κάτω άκρων» (ΜΩΒ). Σχετίζεται με μια σειρά ασθενειών, συμπεριλαμβανομένης της χρόνιας φλεβικής υπέρτασης και των κιρσών.
☆ Στα αποτελέσματα του Stiftung Warentest του 2022 από τη Γερμανία, η ικανοποίηση των καταναλωτών με το ModelDerm ήταν ελαφρώς χαμηλότερη από ό,τι με τις πληρωμένες διαβουλεύσεις τηλεϊατρικής.
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Το Livedoid vasculopathy είναι μια σπάνια δερματική πάθηση που χαρακτηρίζεται από επώδυνα έλκη που επανέρχονται συνεχώς στα κάτω πόδια.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Το Livedoid vasculopathy είναι μια σπάνια δερματική πάθηση που προκαλεί επαναλαμβανόμενα έλκη στα κάτω πόδια, αφήνοντας πίσω ωχρές ουλές γνωστές ως λευκή ατροφία. Ενώ η ακριβής αιτία είναι ακόμα ασαφής, πιστεύεται ότι η αυξημένη πήξη του αίματος (hypercoagulability) είναι ο κύριος παράγοντας, με τη φλεγμονή να παίζει δευτερεύοντα ρόλο. Οι παράγοντες που συμβάλλουν στην πήξη περιλαμβάνουν τους εξής - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Στις βιοψίες, η κατάσταση εμφανίζει θρόμβους αίματος μέσα στα αγγεία, πάχυνση των τοιχωμάτων των αγγείων και ουλές. Η θεραπεία περιλαμβάνει μια πολύπλευρη προσέγγιση που εστιάζει στην πρόληψη θρόμβων αίματος με φάρμακα όπως αντιαιμοπεταλιακά φάρμακα, αραιωτικά αίματος και ινωδολυτική θεραπεία. Μπορούν να χρησιμοποιηθούν διάφορα φάρμακα για αυτήν την πάθηση του δέρματος - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Το Livedoid vasculopathy είναι μια σπάνια πάθηση όπου εμφανίζονται βλάβες και στα δύο πόδια. Ο σχηματισμός θρόμβων αίματος σε μικροσκοπικά αιμοφόρα αγγεία πιστεύεται ότι προκαλείται από αυξημένη πήξη και μειωμένη διάσπαση του θρόμβου, μαζί με βλάβη στην επένδυση του αγγείου. Είναι πιο συχνό στις γυναίκες, ιδιαίτερα μεταξύ 15 και 50 ετών. Η διακοπή του καπνίσματος, η φροντίδα των πληγών και η χρήση φαρμάκων όπως αραιωτικά αίματος και αντιαιμοπεταλιακά φάρμακα ήταν αποτελεσματικά.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
